英语翻译请帮忙翻译一下一段文字,万分火急,急性双表型白血病(BAL)是一种少见类型的白血病,其具有独特的临床、生物学和预

英语翻译
请帮忙翻译一下一段文字,万分火急,
急性双表型白血病(BAL)是一种少见类型的白血病,其具有独特的临床、生物学和预后特征.BAL的诊断和治疗均不同于单一类型的白血病.因此,我们回顾性分析了6例BAL患者,这些患者均是根据国际白血病欧洲协作组(EGIL)1995年标准而诊断的急性双表型白血病.在本次研究中,我们对这6例BAL骨髓标本分别进行光镜细胞形态学及相关细胞化学染色观察,以确定其FAB类型;应用流式细胞仪做免疫分型,即使用一系列相关单克隆抗体检测细胞膜和细胞质抗原表达情况;同时采用G显带技术进行核型分析;运用兼顾急性髓细胞白血病(AML)及急性淋巴细胞白血病(ALL)的治疗方案治疗本组4例BAL患者.目前,我们发现BAL患者约占同期诊断的急性白血病的9.6%.BAL患者的临床表现与AML及ALL患者的差异无显著意义;形态学上BAL表现为AML-M2、M5和ALL-L3;免疫分型显示BAL患者中以髓系、B系共表达者多见.另外,HLA-DR、CD34在BAL中呈高表达,提示BAL的白血病细胞可能起源于早期造血细胞;核型分析可见异常染色体的出现,但本课题的研究尚无法确认其染色体核型异常是否具有特异性.BAL患者对治疗反应差,病情凶险,预后差.接受治疗的4例BAL患者中,首次化疗1例达完全缓解,占25%.另两例在第二次化疗后达完全缓解,剩下一例进行了第3、4疗程仍未缓解.
zebrahao 1年前 已收到1个回答 举报

Devil313 幼苗

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Biphenotypic acute leukemia (BAL) is a rare type of leukemia,and its unique clinical and biological characteristics and prognosis.BAL in the diagnosis and treatment are different from a single type of leukemia.Therefore,we retrospectively analyzed six cases of BAL patients,these patients are in accordance with the European Cooperative Group International Leukemia (EGIL) 1995 standard and the diagnosis of biphenotypic acute leukemia.In this study,we have six cases of BAL specimens of bone marrow cells by light microscopy,respectively,morphological and cytochemical staining to determine their FAB type; the application of flow cytometry immunophenotyping to do,namely,the use of a series of single - Detection of cell membrane antibodies and antigen expression in the cytoplasm; At the same time,the use of G-banding karyotype analysis techniques; the use of both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) treatment in the treatment of four cases in this group of patients with BAL.At present,we have found about the same period of BAL in patients with the diagnosis of acute leukemia of 9.6%.BAL in patients with clinical manifestations in patients with AML and ALL was no significant difference; morphology on the performance of BAL for the AML-M2,M5 and ALL-L3; Immunophenotyping showed that BAL patients with myeloid,B Department of expression were found .In addition,HLA-DR,CD34 positive in the high expression in BAL,suggesting that BAL may be the origin of the leukemic cells in the early hematopoietic cells; karyotype analysis of chromosome abnormalities can be seen,but the study subjects can not be confirmed whether the abnormal karyotype with specificity.BAL in patients with poor response to treatment,the disease risks of poor prognosis.Four cases of treatment of patients with BAL for the first time of chemotherapy complete remission one cases,accounting for 25%.Another in the second two cases of complete remission after chemotherapy,the remaining case of 3,4 for the first course of treatment has yet to ease.

1年前

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