英语翻译Tissue globins Recent discoveries suggest that a family

英语翻译
Tissue globins
Recent discoveries suggest that a family of tissue globins may function in a similar fashion as myoglobin in other tissues .Neuroglobin and cytoglobin are two members of this family that share sequence homology with myoglobin and contain a heme-binding domain.Consequently,neuroglobin and cytoglobin are both capable of reversibly binding oxygen.While neuroglobin appears to be relatively restricted to the neuronal lineages,cytoglobin appears to be more broadly expressed in many adult tissues including the heart,skeletal muscle and brain.The role of these globin family members remains ill defined but the possibility exists that they may play a compensatory role,in part,in the myoglobin deficient heart and skeletal muscle.
Future perspectives 未来前景
Myoglobin is a dynamic cytoplasmic monomeric hemoprotein that is tissue restricted to cardiomyocytes and oxidative skeletal myofibers.Over the past one hundred years,intense interest has focused on the functional roles of this hemoprotein.Recent studies utilizing transgenic and knockout technologies have generated mice with variable dosages of myoglobin expression.These genetic mouse models have been useful in the definition of important cellular adaptations in response to the reprogramming of gene expression that promotes viability in the absence of myoglobin.In addition,these mouse models have been useful in the definition of functional roles for myoglobin including facilitated oxygen diffusion,oxygen storage,and a scavenger of NO and reactive oxygen species.Future studies will focus on the transcriptional regulation of myoglobin gene expression in response to extreme environmental conditions (i.e.hypoxia and intense exercise).An important question to address is whether myoglobin is a direct downstream target of HIF1α.In addition,the definition of the compensatory or overlapping role(s) for tissue hemoglobins (i.e.myoglobin,cytoglobin,neuroglobin,hemoglobin,etc.) in muscle and non-muscle lineages will be explored in these genetic mutant mouse models.These studies will utilize gene disruption technology and will analyze double or triple mutant mice lacking multiple tissue hemoglobins.Ultimately,an enhanced understanding of the role of myoglobin and other tissue hemoglobins in promoting oxygen delivery and cytoprotection may be useful as therapeutic interventions in patients with congenital or acquired myopathies.