with 和by的区别主要是with 和by后面接的名词的区别比如do sth.+by/with+有关hand

with one’s hand(s) 用手(即不是用口,用脚,用眼睛等).如：We work with our hands.我们用手工作.He stroke the child with his hand.他用手打这个小孩.
by hand (1) 用手工(即不是用机器或其它手段).如：The letter was written by hand.这封信是用手写的(即不是打印的).My shoes were made by hand.我的鞋是手工做的(即不是机器做的).(2) 用专人(即不是通常邮寄等).如：Did the letter come by hand or through the pTOM:0pt; TEXT-INDENT:21pt; LINE-HEIGHT:ost?这封信是专人送来的还是邮寄来的?