英语翻译There is one issue that stands out above all the rest,on

英语翻译
There is one issue that stands out above all the rest,one in which every American is concerned,regardless of what group he may belong to.
In spite of the obvious differences in size and population,the states of america have many things in common.这句不用翻译,我想问问开头的in spite of为什么不能换成though