英语翻译MMP-2 digests native collagen types I,II and III in a si
英语翻译
MMP-2 digests native collagen types I,II and III in a similar manner to the collagenases,but MMP-9 does not.However,the collagenolytic activity of MMP-2 is much weaker than MMP-1 or other collagenases in solution.Nevertheless,because proMMP-2 is recruited to the cell surface and activated by the membrane-bound MT-MMPs,it may accumulate pericellularly and express reasonable local collagenolytic activity.It may also act as a ‘collaborator’ activity,digesting collagenaseclipped collagen to smaller fragments because those fragments denature at body temperature 37 °C .
MMP-2 digests native collagen types I,II and III in a similar manner to the collagenases,but MMP-9 does not.However,the collagenolytic activity of MMP-2 is much weaker than MMP-1 or other collagenases in solution.Nevertheless,because proMMP-2 is recruited to the cell surface and activated by the membrane-bound MT-MMPs,it may accumulate pericellularly and express reasonable local collagenolytic activity.It may also act as a ‘collaborator’ activity,digesting collagenaseclipped collagen to smaller fragments because those fragments denature at body temperature 37 °C .
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