what's worry with you?与what’s matter with you?的区别

In language & linguistics,these two questions are similar in meaning but literature don't.It's because literature focus on indentified vocabulary and linguisitcs focus on word.What are the diferent from these field?To put it in a nushall,linguistics depends on intonation as well as situations; literature depends on literary and rehortics used.
These two questions have two or above meanings each other.They determined conversation and situation indeed.