英语翻译The transport of hydrophilic macromolecules via the para
英语翻译
The transport of hydrophilic macromolecules via the paracellular pathway is,however,
severely restricted by the presence of tight junctions which are located at the luminal aspect of adjacent epithelial cells.[ 5 ]Tight junctions consist of a complex of trans-membrane (e.g.,occuludin,claudin,JAM) and cytoplasmic (e.g.,ZO-1,ZO-2,ZO-3,cingulin) proteins and are dynamically regulated by complex physiological mechanisms.[ 6 ] ZO-1 proteins are thought to be a linkage molecule between occludin and actin cytoskeleton and play important roles in the rearrangement of cell–cell contacts.