the difference in 与 the difference of 的区别?

the difference in 与 the difference of 的区别?
查剑桥英英字典的 difference 的词条,有例句：
1.We'd like better seats,but if the difference in price is too much,we'll keep what we have.
2.There was a difference of opinion about the best way to run the business,and as a rusult I left the company.
那 the difference in 与 the difference of 有什么区别呢?我看到词条的解释当中有：
2.A difference of opinion is a disagreement.
那是不是 the difference of 只在 a difference of opinion 中使用呢?
请各位赐教.