There are two major problems linked with atomic power plants

There are two major problems linked with atomic power plants,the first ________ concerns nuclear waste.
1.of both
2.of whom
3.of which
4.of the two
of both 和 of the two 有何不妥?
那of both和of the two用在什么场合？有些什么例子？
这两个在句中引起：
1.语法错误
2.意思错了
3.习惯上的错误
这三个中哪些？
另外of both和of the both是否有区别呢？of the both是否适合本题？