翻译文献片段,麻烦人工翻译,翻译好的话可以加分

翻译文献片段,麻烦人工翻译,翻译好的话可以加分
Another well-studied gene is the opioid receptor μ1 (OPRM1) that exhibits a polymorphism 27 and is related not only to pain sensitivity,28-31 but also to opioid consumption and development of side effects.32 Furthermore, there is some preliminary evidence that significant synergistic effects exist in patients who possess both COMT and OPRM1 polymorphisms with respect to a predisposition to experiencing pain.33
Furthermore, recent studies 34 have demonstrated that the expression of the opioid receptors can be modified by virally mediated gene transfer in afferent neurons. In particular, an increased expression is associated with the administration of a lower dose of peripheral opioids to produce adequate analgesia. Accordingly, this strategy may be used in treating neuropathic pain to avoid the dose-limiting and central nervous system-mediated side effects such as sedation and addiction. Another promising field of research about genetics and pain is related to voltage-gated channels. 35 These ion channels could be implicated in the perception of pain, response to a new classof specific analgesic drugs, and defining the potential risk of a patient developing chronic pain. The candidate genes are SCN9A for sodium channels,36, 37 CNA1B 38 for calcium channels, and KCNQ2 39, 40 and KCNQ339 for potassium channels.